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Meta-analysis of the effects of garlic on diastolic blood pressure (DBP) in hypertensive adults. a2400, Allicor-2400mg group; h, hypertensive subgroup; IV, inverse variance method; SD, standard deviation. lose weight – find out what your ideal weight is using the BMI healthy weight calculator and read advice about losing weight if you're overweight Eight out of the 12 trials used garlic powder, either Kwai manufactured in Germany (n=5) ( 28– 32), Allicor from Russia (n=2) ( 33, 34), or a garlic powder manufactured in Japan (n=1) ( 35), while 4 trials investigated Kyolic aged garlic extract ( 5– 8). Kyolic aged garlic extract powder is manufactured from organically grown garlic bulbs, which has undergone a 20-month aging process in 70% ethanol at room temperature. During the aging process, volatile sulphur components found in raw garlic, such as allicin, are chemically converted into stable and standardisable components, including the main vasoactive component, SAC ( 38– 40).
Kwai Blood Pressure – a blend of nutrients specifically selected to help maintain normal blood pressure and heart muscle function. Furthermore, previous research suggests that garlic is effective in normalising blood cholesterol levels. A meta-analysis of 39 trials and 2,300 participants demonstrated an improvement in total cholesterol and low-density-lipoprotein (LDL) in adults with slightly elevated levels at baseline ( 44).
Possible side effects include dizziness, headaches, tiredness, and cold hands and feet. High blood pressure in older people
Not all participants of the trials included in the meta-analysis on systolic hypertension also suffered from diastolic hypertension. Eight out of the 12 trials involving 374 subjects met the inclusion criteria for the meta-analysis of diastolic hypertension ( 7, 8, 28– 30, 32, 34, 35). Food Supplement Ingredients Potassium Chloride, Magnesium Oxide, Bulking Agents (Cellulose, Cross-Linked Sodium Carboxymethyl Cellulose), Anti-Caking Agents (Mono- and Diglycerides of Food Fatty Acids, Magnesium Salts of Food Fatty Acids, Silicon Dioxide, Talcum), Hydrogenated Palm Oil, Coating (Hydroxypropylmethyl Cellulose, Polyethylenglycol), Ferrous Fumarate, Vitamin B6 (as Pyridoxine Hydrochloride), Zinc Oxide, Vitamin B12 (as Cyanocobalamin), Colour Titanium DioxideIt's really important to take your medicine as directed. If you miss doses, it will not work as well. Briefly, the mechanisms of action through which garlic influences blood pressure involve two main signalling pathways via nitric oxide (NO) and hydrogen sulphide (H 2S) production ( 16). Garlic, a sulphur donor, provides an important component for the trans-sulphuration pathway, which is linked to the methylation pathway, with both requiring several co-factors, such as vitamin B12, folate, vitamin B2 and vitamin B6. In addition, known genetic variants for the cystathionine-β-synthase (CBS) and cystathionine-γ-lyase (CSE) enzymes influence the efficiency of H 2S production, and thus are considered to play an important role in the susceptibility to developing hypertension, in conjunction with deficiencies in B vitamins. We have previously identified a potentially large proportion (80%) of healthy adults in Australia with sub-optimal vitamin B12 levels (<500 pg/l) ( 17). Therefore, deficiencies in co-factors, such as vitamin B12, may explain the individual responsiveness of blood pressure to garlic observed in our clinical trials. In our third ‘AGE at Heart’ trial we found Kyolic to be effective in reducing peripheral blood pressure, as well as central blood pressure, central pulse pressure, pulse wave velocity and arterial stiffness ( 7). Central hemodynamic measures, such as central blood pressure, pulse wave velocity, pulse pressure and arterial stiffness, are regarded as more important predictors than peripheral blood pressure for cardiovascular disease risk ( 11, 12). Arterial stiffness, an indicator of the flexibility of the arteries, increases with age through the loss of intact elastin and collagen fibres in the arterial wall ( 13, 14), which also contributes to increased blood pressure ( 15). Kyolic aged garlic extract has been shown to be effective in reducing arterial stiffness, which in turn is related to better heart health and aerobic fitness, while the risk of cardiovascular disease is reduced ( 7, 8, 12).
The included trials were of high quality with a minimal risk of bias ( Figs. 1 and and2). 2). An unclear risk of attrition bias was encountered in 2 trials ( 28, 29), which did not report on the loss to follow-up, one trial ( 32) reported 20% attrition in the garlic group and 11% in the placebo group, and another trial ( 33) reported 27% attrition in the garlic group, and none in the placebo group. No details on blood pressure measurements were reported in 2 trials ( 32, 33), leading to an unclear risk of detection bias, and no details on allocation concealment were reported in another trial ( 30). Resulting in an unclear risk of selection bias.
Possible side effects include dizziness when standing up, increased thirst, needing to go to the toilet frequently, and a rash. ARBs work in a similar way to ACE inhibitors. They're often recommended if ACE inhibitors cause troublesome side effects. It's now thought that if you reach 80 while you're taking medicine for high blood pressure, it's fine to continue treatment provided it's still helping you and is not causing side effects.
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