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Yi, H.; Sun, T.; Armstrong, D.; Borneman, S.; Yang, C.; Austin, S.; Kishnani, P.S.; Sun, B. Antibody-mediated enzyme replacement therapy targeting both lysosomal and cytoplasmic glycogen in Pompe disease. J. Mol. Med. 2017, 95, 513–521. [ Google Scholar] [ CrossRef] [ PubMed] Wuornos was born in 1956 in Michigan. Her father was a violent, convicted child molester who completed suicide by hanging while serving a prison sentence. Her mother, Diane, was 15 years old when she married Wuornos’ father. She abandoned Wuornos and her older brother Keith to the care of their maternal grandparents after her husband’s death. Wuornos’ alcoholic grandmother and violent, volatile grandfather raised both children. 81 Wuornos told clinical examiners that her grandfather sexually abused her, as did one of his friends. 82 She also reported having an incestuous relationship with her brother. 83 Wang, C. Efficacy and Safety of Zoledronic Acid for Treatment of Postmenopausal Osteoporosis: A Meta-Analysis of Randomized Controlled Trials. Am. J. Ther. 2017, 24, e544–e552. [ Google Scholar] [ CrossRef] [ PubMed] There are the obvious advantages to being able to reach employees wherever they are without the need for an in-person interaction. These solutions can be highly effective in resolving minor acute MSK conditions and in a lot of cases in reducing chronic pain caused by older conditions.
Zeniou, M., Ding, T., Trivier, E. & Hanauer, A. Expression analysis of RSK gene family members: the RSK2 gene, mutated in Coffin–Lowry syndrome, is prominently expressed in brain structures essential for cognitive function and learning. Hum. Mol. Gen. 11, 2929–2940 (2002). Sutherland, C., Leighton, I. A. & Cohen, P. Inactivation of glycogen synthase kinase-3 β by phosphorylation: new kinase connections in insulin and growth-factor signalling. Biochem. J. 296, 15–19 (1993).Shahbazian, D. et al. The mTOR/PI3K and MAPK pathways converge on eIF4B to control its phosphorylation and activity. EMBO J. 25, 2781–2791 (2006).
Carriere, A., Ray, H., Blenis, J. & Roux, P. P. The RSK factors of activating the Ras/MAPK signaling cascade. Front. Biosci. 13, 4258–4275 (2008). McManus, M. T. & Sharp, P. A. Gene silencing in mammals by small interfering RNAs. Nature Rev. Genet. 3, 737–747 (2002). Smith, J. A. et al. Identification of the first specific inhibitor of p90 ribosomal S6 kinase (RSK) reveals an unexpected role for RSK in cancer cell proliferation. Cancer research 65, 1027–1034 (2005). Zhang, J.; Wang, R.; Zhao, Y.-L.; Sun, X.-H.; Zhao, H.-X.; Tan, L.; Chen, D.-C.; Hai-Bin, X. Efficacy of intravenous zoledronic acid in the prevention and treatment of osteoporosis: A meta-analysis. Asian Pac. J. Trop. Med. 2012, 5, 743–748. [ Google Scholar] [ CrossRef][ Green Version]Park, J.; Yan, G.; Kwon, K.C.; Liu, M.; Gonnella, P.A.; Yang, S.; Daniell, H. Oral delivery of novel human IGF-1 bioencapsulated in lettuce cells promotes musculoskeletal cell proliferation, differentiation and diabetic fracture healing. Biomaterials 2020, 233, 119591. [ Google Scholar] [ CrossRef] Soloaga, A. et al. MSK2 and MSK1 mediate the mitogen- and stress-induced phosphorylation of histone H3 and HMG-14. EMBO J. 22, 2788–2797 (2003). Ballif, B. A. & Blenis, J. Molecular mechanisms mediating mammalian mitogen-activated protein kinase (MAPK) kinase (MEK)–MAPK cell survival signals. Cell Growth Differ. 12, 397–408 (2001). Jensen, C. J. et al. 90-kDa ribosomal S6 kinase is phosphorylated and activated by 3-phosphoinositide-dependent protein kinase-1. J. Biol. Chem. 274, 27168–27176 (1999). Provided evidence for the phosphorylation of RSK2 by PDK1, thus extending the findings which implicated PDK1 in the activation of AKT/PKB, PKC and S6K, and suggesting that PDK1 controls several crucial growth factor-activated signal-transduction pathways.
Liang, C.; Guo, B.; Wu, H.; Shao, N.; Li, D.; Liu, J.; Dang, L.; Wang, C.; Li, H.; Li, S.; et al. Aptamer-functionalized lipid nanoparticles targeting osteoblasts as a novel RNA interference–based bone anabolic strategy. Nat. Med. 2015, 21, 288–294. [ Google Scholar] [ CrossRef] FSKs have held a wide variety of jobs, including sex worker, drug dealer, psychic, food server, farmer, and Sunday school (religious) teacher. However, an alarming number of serial killers (39%) have worked in health-related positions (e.g., nurses and nurse’s aides). In addition, more than one out of five has held another direct caregiver role (e.g., stay-at-home mother, stay-at-home wife, babysitter). That means that most (more than 60%) of FSKs were in charge of others’ well-being, particularly of those who are vulnerable. Mitigating factors in the case were drawn from her life story. She grew up as an orphan, for example, and her alcoholic, adoptive parents abused her and her many siblings. The Los Angeles Times reported that Puente’s mother was a prostitute who died when Puente was 10, and that her father would hold a pistol to his head and threaten suicide in front of the children. After her mother’s death, she spent time in an orphanage and many foster homes. At age 16, she was sexually abused. The jury also heard that, at times, she was kind and generous. 16 Digital Solutions in MSK care are not new; however, have seen a great insurgence in market share due to the COVID-19 pandemic Balmayor, E.R. Targeted delivery as key for the success of small osteoinductive molecules. Adv. Drug. Deliv. Rev. 2015, 94, 13–27. [ Google Scholar] [ CrossRef]
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Filipowska, J.; Tomaszewski, K.A.; Niedźwiedzki, Ł.; Walocha, J.A.; Niedźwiedzki, T. The role of vasculature in bone development, regeneration and proper systemic functioning. Angiogenesis 2017, 20, 291–302. [ Google Scholar] [ CrossRef][ Green Version] Schouten, G. J. et al. IκB α is a target for the mitogen-activated 90 kDa ribosomal S6 kinase. EMBO J. 16, 3133–3144 (1997).
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