Rowatinex Soft Capsules

Product Information

Rats given lethal doses of ROWATINEX orally develop a condition similar to narcosis, losing their corrective power and die in deep somnolence. 5. PHARMACOLOGICAL PROPERTIES 5.1 Pharmacodynamic properties Yellow spherical, soft-enteric-coated gelatin capsules containing a pale yellow or greenish yellow oil. 4. CLINICAL PARTICULARS 4.1 Therapeutic indications Doza uzuala este de 1-2 picaturi orale, solutie Rowatinex de 3-4 ori pe zi, cu 30 minute inainte de mese sau conform recomandarii medicului.

Do not take a double dose to make up for a forgotten dose. Just take it as soon as you remember. Then go on taking your next dose at the usual time. Trebuie avute in vedere precautii la pacientii tratati cu anticoagulante sau alte medicamente metabolizate la nivel hepatic care au un indice terapeutic mic. If any of the side effects gets serious, or if you notice any side effects notlisted in this leaflet, please tell your doctor or pharmacist. Rowatinex® contains essential oils that help to dissolve or break down and remove (disintegrating and eliminating) kidney and urinary tract stones. The exact mechanism of action of Rowatinex is not yet fully known. In preclinical experiments, it was confirmed that Rowatinex has antilithogenic, antibacterial, anti-inflammatory, spasmolytic, and analgesic properties [ 14, 15]. The antilithogenic property, which influences renal oxalate lithogenesis, is important because most urinary stones are composed of calcium oxalate aggregates. Inhibition of remnant stone formation originating after SWL might increase the long-term success rate of SWL [ 16]. In addition, Rowatinex has shown antibacterial effects against a variety of pathogens [ 10]. Rowatinex has anti-inflammatory and analgesic properties derived from cineole and anethole, which are important to patients who have urolithiasis with spasm, inflammation, pain, and infection [ 17, 18]. According to Horvath [ 19], Rowatinex and its single terpenes-such as camphene, cineole, and borneol- have antispasmodic effects on smooth muscle preparations in animal models. Djaladat et al. [ 7] reported that Rowatinex increases urine excretion by increasing renal blood flow and has antispasmodic effects that may help with the expulsion of renal stone. Engelstein et al. [ 11], in their prospective, randomized, and double-blind study, showed that the expulsion rate of ureteral stones in the Rowatinex group was greater than that in the placebo group in 87 patients in the emergency room (81% compared with 59%). However, the number of subjects in that study was small, and the authors did not consider stone size and treatment duration. In a randomized trial conducted by Romics et al. [ 10], the expulsion rate of urinary stones was greater and the treatment duration was shorter in the Rowatiex group than in the placebo group; no significant differences in age, sex, or stone size were found between the two groups. The expulsion rate of urinary stones 2 weeks after the initial SWL was not significantly different between the two groups (37.4% compared with 35.5%, p=0.684). However, 4 weeks after the initial SWL, the cumulative expulsion rate of ureteral stones in group 1 was greater than that in group 2 (72.2% compared with 61.1%, p=0.022). This result indicates that Rowatiex was not effective at stone expulsion in the short term, but was effective over a treatment period of 4 weeks.

Rowatinex® relieves muscle spasm thus reducing the pain of kidney and urinary colics. Rowatinex® is also used to relieve the effects associated withmild urinary tract infections. 2. Before you take Rowatinex® If you have any further questions on the use of this product, ask your doctor or pharmacist. 4. Possible Side Effects All problems (adverse events) related to a medicine or medical device used for treatment or in a procedure should be reported to the Medicines and Healthcare products Regulatory Agency using the Yellow Card Scheme. Ocazional, au fost raportate tulburari gastrice usoare si tranzitorii. Rar, au fost semnalate varsaturi. S-au raportat doua cazuri usoare de intoleranta medicamentoasa. Pot sa apara reactii alergice, chiar intarziate (vezi pct. Precautii). You should not take Rowatinex® in early pregnancy (the first trimester) or if you are breast feeding. No harmful effects on babies have been reported,but the risk is still unknown.

Do not take a double dose to make up for a forgotten dose. Just take it as soon as you remember. Then go on taking your next dose at the usualtime.

Prospect Rowatinex x 30 caps.

In caz de supradozaj pot sa apara iritatie gastrica cu greata, varsaturi si diaree. Daca medicamentul a fost inghitit de putin timp, se va efectua lavaj gastric. Pacientul trebuie supravegheat cu atentie si, daca este necesar, se va institui tratament simptomatic. Trebuie monitorizate functiile cardiaca, respiratorie, renala si hepatica. Studiile toxicologice la animale au evidentiat faptul ca dozele mari de uleiuri esentiale pot provoca deprimarea sistemului nervos central cu stare de stupoare si insuficienta respiratorie sau stimularea sistemului nervos central pana la stare de excitatie si convulsii. ROWATINEX promotes the disintegration and elimination of renal and urinary tract stones. Terpenes such as Borneol are metabolised and excreted inthe urine mainly. In the form of glucuronides, which increase the solubility ofcalcium salts [the main components of renal and urinary stones]. Theinhibitory effect of ROWATINEX on the formation of renal and urinarycalculi has been established in a number of animal studies.