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Laclau MN, et al. Cardioprotection by ischemic preconditioning preserves mitochondrial function and functional coupling between adenine nucleotide translocase and creatine kinase. J Mol Cell Cardiol. 2001;33(5):947–56. Juhasz I, et al. Creatine supplementation improves the anaerobic performance of elite junior fin swimmers. Acta Physiol Hung. 2009;96(3):325–36.

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Evangeliou A, et al. Clinical applications of creatine supplementation on paediatrics. Curr Pharm Biotechnol. 2009;10(7):683–90. Boudina S, et al. Alteration of mitochondrial function in a model of chronic ischemia in vivo in rat heart. Am J Physiol Heart Circ Physiol. 2002;282(3):H821–31. Greenhaff PL, et al. Influence of oral creatine supplementation of muscle torque during repeated bouts of maximal voluntary exercise in man. Clin Sci (Lond). 1993;84(5):565–71. Cancela P, et al. Creatine supplementation does not affect clinical health markers in football players. Br J Sports Med. 2008;42(9):731–5.

Creatine Powder - 1kg / 1000 g - Pure Creatin Monohydrate Creatine Powder - 1kg / 1000 g - Pure Creatin Monohydrate

A number of studies have investigated the short and long-term therapeutic benefit of creatine supplementation in children and adults with various neuromuscular diseases like muscular dystrophies [ 160, 161, 162, 163, 164, 165], Huntington’s disease [ 23, 166, 167, 168, 169, 170, 171]; Parkinson disease [ 23, 40, 166, 172, 173, 174]; mitochondria-related diseases [ 29, 175, 176, 177]; and, amyotrophic lateral sclerosis or Lou Gehrig’s Disease [ 166, 178, 179, 180, 181, 182, 183, 184]. These studies have provided some evidence that creatine supplementation may improve exercise capacity and/or clinical outcomes in these patient populations. However, Bender and colleagues [ 23] recently reported results of several large clinical trials evaluating the effects of creatine supplementation in patients with Parkinson’s disease (PD), Huntington’s disease (HD), and amyotrophic lateral sclerosis (ALS). A total of 1,687 patients took an average of 9.5 g/day of creatine for a total of 5,480 patient years. Results revealed no clinical benefit on patient outcomes in patients with PD or ALS. However, there was some evidence that creatine supplementation slowed down progression of brain atrophy in patients with HD (although clinical markers were unaffected). Whether creatine supplementation may have a role in mediating other clinical markers in these patient populations and/or whether individual patients may respond more positively to creatine supplementation than others, remain to be determined. Nevertheless, these studies show that creatine supplementation has been used to treat children and adults with neurodegenerative conditions and is apparently safe and well-tolerated when taking up to 30 g/day for 5 years in these populations. Ischemic heart disease McMorris T, et al. Effect of creatine supplementation and sleep deprivation, with mild exercise, on cognitive and psychomotor performance, mood state, and plasma concentrations of catecholamines and cortisol. Psychopharmacology (Berl). 2006;185(1):93–103. Mazzini L, et al. Effects of creatine supplementation on exercise performance and muscular strength in amyotrophic lateral sclerosis: preliminary results. J Neurol Sci. 2001;191(1–2):139–44. Weiss BA, Powers ME. Creatine supplementation does not impair the thermoregulatory response during a bout of exercise in the heat. J Sports Med Phys Fitness. 2006;46(4):555–63.

Jacobs PL, et al. Oral creatine supplementation enhances upper extremity work capacity in persons with cervical-level spinal cord injury. Arch Phys Med Rehabil. 2002;83(1):19–23. Creatine Monohydrate, Flavouring, Acid (Citric Acid), Sweetener (Sucralose), Colour (Beetroot Red). Allergens Everyone knows getting enough protein is essential for improving muscle growth and overall athletic performance. But unfortunately, it can get expensive! Fret not. Here are the cheapest protein powders that are still worth buying in 2023. Our strong recommendation for the best cheap protein powder…

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Braissant O. Creatine and guanidinoacetate transport at blood–brain and blood-cerebrospinal fluid barriers. J Inherit Metab Dis. 2012;35(4):655–64. Conorev EA, Sharov VG, Saks VA. Improvement in contractile recovery of isolated rat heart after cardioplegic ischaemic arrest with endogenous phosphocreatine: involvement of antiperoxidative effect? Cardiovasc Res. 1991;25(2):164–71.Hespel P, et al. Oral creatine supplementation facilitates the rehabilitation of disuse atrophy and alters the expression of muscle myogenic factors in humans. J Physiol. 2001;536(Pt 2):625–33. Choi JK, et al. Magnetic resonance spectroscopy of regional brain metabolite markers in FALS mice and the effects of dietary creatine supplementation. Eur J Neurosci. 2009;30(11):2143–50. A growing collection of evidence supports that creatine supplementation may improve health status as individuals age [ 41, 43, 44, 45, 195]. In this regard, creatine supplementation has been reported to help lower cholesterol and triglyceride levels [ 67, 196]; reduce fat accumulation in the liver [ 197]; reduce homocysteine levels [ 198]; serve as an antioxidant [ 199, 200, 201, 202]; enhance glycemic control [ 132, 203, 204, 205]; slow tumor growth in some types of cancers [ 32, 198, 206, 207]; increase strength and/or muscle mass [ 37, 41, 44, 45, 82, 208, 209, 210, 211, 212]; minimize bone loss [ 211, 212]; improve functional capacity in patients with knee osteoarthritis [ 213] and fibromyalgia [ 214]; positively influence cognitive function [ 43, 83, 195]; and in some instances, serve as an anti-depressant [ 215, 216, 217]. Kreider RB. Effects of creatine supplementation on performance and training adaptations. Mol Cell Biochem. 2003;244(1–2):89–94. Tarnopolsky MA, MacLennan DP. Creatine monohydrate supplementation enhances high-intensity exercise performance in males and females. Int J Sport Nutr Exerc Metab. 2000;10(4):452–63.

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Rawson ES, Clarkson PM. Acute creatine supplementation in older men. Int J Sports Med. 2000;21(1):71–5. Poortmans JR, Francaux M. Long-term oral creatine supplementation does not impair renal function in healthy athletes. Med Sci Sports Exerc. 1999;31(8):1108–10. Braissant O, et al. Creatine deficiency syndromes and the importance of creatine synthesis in the brain. Amino Acids. 2011;40(5):1315–24. After reviewing the scientific and medical literature in this area, the International Society of Sports Nutrition concludes the following in terms of creatine supplementation as the official Position of the Society:Santacruz L, Jacobs DO. Structural correlates of the creatine transporter function regulation: the undiscovered country. Amino Acids. 2016;48(8):2049–55. Patra S, et al. A short review on creatine-creatine kinase system in relation to cancer and some experimental results on creatine as adjuvant in cancer therapy. Amino Acids. 2012;42(6):2319–30.